Anomalous Breaking of Anisotropic Scaling Symmetry in the Quantum Lifshitz Model

In this note we investigate the anomalous breaking of anisotropic scaling symmetry in a non-relativistic field theory with dynamical exponent z=2. On general grounds, one can show that there exist two possible "central charges" which characterize the breaking of scale invariance. Using heat kernel methods, we compute these two central charges in the quantum Lifshitz model, a free field theory which is second order in time and fourth order in spatial derivatives. We find that one of the two central charges vanishes. Interestingly, this is also true for strongly coupled non-relativistic field theories with a geometric dual described by a metric and a massive vector field.Comment: 26 pages; major revision (results were unaffected), published versio

SUCI02 inhibits the erbB-2 tyrosine kinase receptor signaling pathway and arrests the cell cycle in G 1 phase in breast cancer cells

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73321/1/j.1349-7006.2006.00143.x.pd

Analytic Lifshitz black holes in higher dimensions

We generalize the four-dimensional R^2-corrected z=3/2 Lifshitz black hole to a two-parameter family of black hole solutions for any dynamical exponent z and for any dimension D. For a particular relation between the parameters, we find the first example of an extremal Lifshitz black hole. An asymptotically Lifshitz black hole with a logarithmic decay is also exhibited for a specific critical exponent depending on the dimension. We extend this analysis to the more general quadratic curvature corrections for which we present three new families of higher-dimensional D>=5 analytic Lifshitz black holes for generic z. One of these higher-dimensional families contains as critical limits the z=3 three-dimensional Lifshitz black hole and a new z=6 four-dimensional black hole. The variety of analytic solutions presented here encourages to explore these gravity models within the context of non-relativistic holographic correspondence.Comment: 14 page

Holographic Renormalization for Asymptotically Lifshitz Spacetimes

A variational formulation is given for a theory of gravity coupled to a massive vector in four dimensions, with Asymptotically Lifshitz boundary conditions on the fields. For theories with critical exponent z=2 we obtain a well-defined variational principle by explicitly constructing two actions with local boundary counterterms. As part of our analysis we obtain solutions of these theories on a neighborhood of spatial infinity, study the asymptotic symmetries, and consider different definitions of the boundary stress tensor and associated charges. A constraint on the boundary data for the fields figures prominently in one of our formulations, and in that case the only suitable definition of the boundary stress tensor is due to Hollands, Ishibashi, and Marolf. Their definition naturally emerges from our requirement of finiteness of the action under Hamilton-Jacobi variations of the fields. A second, more general variational principle also allows the Brown-York definition of a boundary stress tensor.Comment: 34 pages, Added Reference

Pathologies in Asymptotically Lifshitz Spacetimes

There has been significant interest in the last several years in studying possible gravitational duals, known as Lifshitz spacetimes, to anisotropically scaling field theories by adding matter to distort the asymptotics of an AdS spacetime. We point out that putative ground state for the most heavily studied example of such a spacetime, that with a flat spatial section, suffers from a naked singularity and further point out this singularity is not resolvable by any known stringy effect. We review the reasons one might worry that asymptotically Lifshitz spacetimes are unstable and employ the initial data problem to study the stability of such systems. Rather surprisingly this question, and even the initial value problem itself, for these spacetimes turns out to generically not be well-posed. A generic normalizable state will evolve in such a way to violate Lifshitz asymptotics in finite time. Conversely, enforcing the desired asymptotics at all times puts strong restrictions not just on the metric and fields in the asymptotic region but in the deep interior as well. Generically, even perturbations of the matter field of compact support are not compatible with the desired asymptotics.Comment: 36 pages, 1 figure, v2: Enhanced discussion of singularity, including relationship to Gubser's conjecture and singularity in RG flow solution, plus minor clarification

Semantic inferentialism as (a form of) active externalism

Within contemporary philosophy of mind, it is taken for granted that externalist accounts of meaning and mental content are, in principle, orthogonal to the matter of whether cognition itself is bound within the biological brain or whether it can constitutively include parts of the world. Accordingly, Clark and Chalmers (Analysis 58(1):7–19, 1998) distinguish these varieties of externalism as ‘passive’ and ‘active’ respectively. The aim here is to suggest that we should resist the received way of thinking about these dividing lines. With reference to Brandom’s (1994, 2000, Inquiry 47:236–253, 2008) broad semantic inferentialism, we show that a theory of meaning can be at the same time a variety of active externalism. While we grant that supporters of other varieties of content externalism (e.g., Putnam 1975 and Burge (Philosophical Review 95:3–45, 1986) can deny active externalism, this is not an option for semantic inferentialists: On this latter view, the role of the environment (both in its social and natural form) is not ‘passive’ in the sense assumed by the alternative approaches to content externalism

Deformations of Lifshitz holography

The simplest gravity duals for quantum critical theories with z=2 `Lifshitz' scale invariance admit a marginally relevant deformation. Generic black holes in the bulk describe the field theory with a dynamically generated momentum scale Lambda as well as finite temperature T. We describe the thermodynamics of these black holes in the quantum critical regime where T >> Lambda^2. The deformation changes the asymptotics of the spacetime mildly and leads to intricate UV sensitivities of the theory which we control perturbatively in Lambda^2/T.Comment: 1+27 pages, 12 figure

Lovelock-Lifshitz Black Holes

In this paper, we investigate the existence of Lifshitz solutions in Lovelock gravity, both in vacuum and in the presence of a massive vector field. We show that the Lovelock terms can support the Lifshitz solution provided the constants of the theory are suitably chosen. We obtain an exact black hole solution with Lifshitz asymptotics of any scaling parameter $z$ in both Gauss-Bonnet and in pure 3rd order Lovelock gravity. If matter is added in the form of a massive vector field, we also show that Lifshitz solutions in Lovelock gravity exist; these can be regarded as corrections to Einstein gravity coupled to this form of matter. For this form of matter we numerically obtain a broad range of charged black hole solutions with Lifshitz asymptotics, for either sign of the cosmological constant. We find that these asymptotic Lifshitz solutions are more sensitive to corrections induced by Lovelock gravity than are their asymptotic AdS counterparts. We also consider the thermodynamics of the black hole solutions and show that the temperature of large black holes with curved horizons is proportional to $r_0^z$ where $z$ is the critical exponent; this relationship holds for black branes of any size. As is the case for asymptotic AdS black holes, we find that an extreme black hole exists only for the case of horizons with negative curvature. We also find that these Lovelock-Lifshitz black holes have no unstable phase, in contrast to the Lovelock-AdS case. We also present a class of rotating Lovelock-Lifshitz black holes with Ricci-flat horizons.Comment: 26 pages, 10 figures, a few references added, typo fixed and some comments have been adde

Black holes and black branes in Lifshitz spacetimes

We construct analytic solutions describing black holes and black branes in asymptotically Lifshitz spacetimes with arbitrary dynamical exponent z and for arbitrary number of dimensions. The model considered consists of Einstein gravity with negative cosmological constant, a scalar, and N U(1) gauge fields with dilatonic-like couplings. We study the phase diagrams and thermodynamic instabilities of the solution, and find qualitative differences between the cases with 12.Comment: 27 pages, 10 figures; v2 references added, minor comments adde

Microarray evidence of glutaminyl cyclase gene expression in melanoma: implications for tumor antigen specific immunotherapy

BACKGROUND: In recent years encouraging progress has been made in developing vaccine treatments for cancer, particularly with melanoma. However, the overall rate of clinically significant results has remained low. The present research used microarray datasets from previous investigations to examine gene expression patterns in cancer cell lines with the goal of better understanding the tumor microenvironment. METHODS: Principal Components Analyses with Promax rotational transformations were carried out with 90 cancer cell lines from 3 microarray datasets, which had been made available on the internet as supplementary information from prior publications. RESULTS: In each of the analyses a well defined melanoma component was identified that contained a gene coding for the enzyme, glutaminyl cyclase, which was as highly expressed as genes from a variety of well established biomarkers for melanoma, such as MAGE-3 and MART-1, which have frequently been used in clinical trials of melanoma vaccines. CONCLUSION: Since glutaminyl cyclase converts glutamine and glutamic acid into a pyroglutamic form, it may interfere with the tumor destructive process of vaccines using peptides having glutamine or glutamic acid at their N-terminals. Finding ways of inhibiting the activity of glutaminyl cyclase in the tumor microenvironment may help to increase the effectiveness of some melanoma vaccines